The twelfth house from the karakamsa is called the Jivanmuktamsa. This is the house signifying the emancipation of the soul and we have to examine this house in order to find one's Ishta Devata.http://www.trendingastro.com/Home/Karakamsa
http://www.astrologykrs.com/karakamsa.html
“When looking at the placement of atmakarkaa in navamsa, you should see what planet is sitting in 12th from the atmakarka planet, if any. This will tell what will happen to the soul. A malefic planet like Saturn, Mars or Rahu sitting 12th from atmakarka or Karakamsa shows that souls still has many lessons to learn before elevating itself to a higher plain. If a benefic planet sits 12th from karakamsa, it shows that the soul has reached a point where it will move to the higher world after the death of physical body. Ketu sitting 12th from karakamsa means the soul will not go to any higher world, rather it will go back to the source energy and finally receive moksha, as in no longer returning to any dimenison for eternity, unless it wants to come back.”
http://astro786.com/2019/08/22/karakamsa-lagna/
“One thing you can see with karakamsa is the soul capacity to arrive at the following degree of salvation or a higher recurrence world. When taking a gander at the situation of atmakarkaa in navamsa, you should perceive what planet is sitting in twelfth from the atmakarka planet, assuming any. This will determine what will happen to the soul. A malefic planet like Saturn, Mars or Rahu sitting twelfth from atmakarka or Karakamsa demonstrates that soul still has numerous exercises to learn before raising itself to a higher plain. If there is a benefic planet sits twelfth from karakamsa, it demonstrates that the soul has arrived at a point where it will move to the higher world after the demise of physical body. Ketu sitting twelfth from karakamsa implies the soul won’t go to any higher world, rather it will return to the source vitality lastly get moksha, as in never again coming back to any dimension for forever, except if it needs to return.”
http://hazratishq.blogspot.com/2012/11/atmakaraka-detailed-analysis-plus.html?m=1
“One will attain final emancipation if Ketu is in the 12th (from Karakamsa) identical with Aries/Sagittarius and is aspected by a benefic.”