posted January 14, 2006 06:18 PM         

"We are now selling 100 IU of Vitamin E because we do not recommend any higher dose than that."

I was really surprised. I thought that we should take higher doses. I have been taking 400 IU 2X day because it is good for circulation and my muscles in my legs. Also I want it for my complexion.

posted January 14, 2006 08:23 PM         

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Vitamin E is another vitamin that is often mistreated. There are extreme side effects of consuming more than the body can absorb. The body’s system only needs one hundred to three hundred milligrams of vitamin E per day. There are vitamin supplements on the market that are sold to help grow nails and hair. These are often abused, you need only to take one tablet per day, and consume at least eight glasses of water per day. If an overdose of vitamin E occurs it could cause blood clots, fatigue, tumors in the breast, and reproductive problems.

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BUT... I also found this:

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If you are concerned about toxicity from taking too much vitamin E, double-blind, placebo-controlled studies of daily intakes of 600 to 3,200 I.U. for three weeks to six months disclosed only a few minor side effects and no major ones.

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...and this:

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Vitamin E: A large review revealed an incidence of non-specific side effects of 0.8%, a figure expected in the non-treated population. Doses up to 3200mg/day have not been found to cause adverse effects but it can exacerbate the effects of vitamin K deficiency. This latter effect is responsible for vitamin E's potentiation of coumadin and it may increase the coagulative function of vitamin K. Vitamin E may increase the inhibition of platelet aggregation cause by aspirin.

The most common side effect from high doses is gastrointestinal with nausea, flatulence and diarrhea. Supplementation can exacerbate hypertension. The water miscible form is preferred in patients with cardiovascular disease and diabetes mellitus since the oily form can increase the serum trigylcerides: vitamin E ratio. Vitamin E may reduce insulin requirements and the insulin dosage in diabetics may need to be readjusted. There are reports of megadoses decreasing thyroid homone but this was not confirmed in a double-blind study. Doses of 40,000 IU/day or more may be teratogenic in pregnancy but doses lower than 10,000 IU/day appear to be safe.

Vitamin E succinate may be more effective in preventing free radical damage than alpha tocopherol. Inorganic (ferric) iron oxidizes and inactivates vitamin E in the intestines but the commonly used supplement, ferrous iron, does not. Vitamin E and selenium have similar mechanisms of action and a clinical deficiency of one can be treated with either nutrient. Zinc deficiency can aggravate the effects of vitamin E deficiency.

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