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Author Topic:   DNA Methylation: Can Your Diet Reduce Your Risk of Disease?
PhoenixRising
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Posts: 744
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Registered: May 2011

posted May 25, 2020 01:11 PM     Click Here to See the Profile for PhoenixRising     Edit/Delete Message   Reply w/Quote
Do investigate your diet plan for the below sources that suppresses bad diseases causing genes. No wonder miso soup containing ( genistein ) is good for you.

- Love.
http://www.healthline.com/health/methylation

quote:

What is DNA methylation?
-------------------------------------

DNA methylation is an example of one of the many mechanisms of epigenetics. Epigenetics refers to inheritable changes in your DNA that don’t change the actual DNA sequence. That means these changes are potentially reversible.

Your DNA consists of four bases, called cytosine, guanine, adenine, and thymine. A chemical unit called a methyl group, which contains one carbon and three hydrogen atoms, can be added to cytosine. When this happens, that area of the DNA is methylated. When you lose that methyl group, the area becomes demethylated.

DNA methylation often inhibits the expression of certain genes. For example, the methylation process might stop a tumor-causing gene from “turning on,” preventing cancer.

Experts are currently working to better understand the factors that affect DNA methylation. Based on their early findings, there’s some evidence that diet plays a role. This opens up the potential to reduce genetic risk of developing certain conditions, such as breast cancer or heart disease, through simple lifestyle changes.

Read on to learn more about DNA methylation, including how to support you own methylation cycle through your diet.

What does the research say?
Research looking at the extent to which DNA methylation affects gene expression is ongoing. Most of these studies have involved animal models or cell samples. However, a few initial studies involving humans have promising results.

DNA methylation status throughout life
The patterns of DNA methylation change throughout your life. The process occurs the most during the stages of early development and later life.

A 2015 reviewTrusted Source found that DNA methylation patterns are constantly changing during fetal development. This allows all of the body’s organs and tissue to form properly.

A 2012 studyTrusted Source further broke down the relationship between DNA methylation and age. People over the age of 100 had less methylated DNA than newborns. People around the age of 26 had methylated DNA levels between those of newborns and centenarians, suggesting that DNA methylation slows down as you age. As a result, genes that were once repressed by methylated DNA start to become active, possible resulting in a variety of diseases.

DNA methylation and diet
The process DNA methylation partly relies on several nutrients.

For example, a 2014 study looked at DNA methylation of tumor cells in women with breast cancer. The study’s investigators found that participants who consumed more alcohol were more likely to have decreased DNA methylation. In contrast, those who consumed a lot of folate were more likely to have increased methylation. These results support the idea that consuming certain nutrients affects DNA methylation.

Some other nutrients that may influence DNA methylation include:

folate
vitamin B-12
vitamin B-6
choline
methionine
polyphenols
genistein, which is found in soy

How can I learn about my own methylation cycle?
Experts use several methods to analyze DNA methylation, depending on the type of information they’re looking for. However, a 2016 reviewTrusted Source of all the potential methods suggests that next-generation sequencing will likely become the standard method in the future. This method is generally more affordable and requires less complex equipment.

Some clinics do offer DNA methylation profile testing. The results of these tests are difficult to interpret, especially in a way that would be meaningful to you. In addition, several online retailers offer kits you can use to collect a sample of your own DNA to send off for analysis. However, they still won’t be able to tell you much about your own methylation cycle.

In the future, analyzing your own DNA methylation profile might be a routine method for preventing certain diseases. But experts still need to figure out how to effectively interpret the results of these tests in a way that’s useful to the general public.



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Randall
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Posts: 128914
From: From a galaxy, far, far away...
Registered: Apr 2009

posted June 06, 2020 03:37 PM     Click Here to See the Profile for Randall     Edit/Delete Message   Reply w/Quote
Bump!

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ilunatique
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Posts: 674
From: neptune
Registered: Jun 2014

posted June 15, 2020 10:34 AM     Click Here to See the Profile for ilunatique     Edit/Delete Message   Reply w/Quote
Regarding this subject,

I learned at my psych Uni that nurturing affects the DNA methylation.
Long story short, if your parents don't nurture you accordingly, your DNA will suffer.

Source: http://www.whatisepigenetics.com/cuddling-can-leave-positive-epigenetic-traces-babys- dna/

Caretaking Adjusts Epigenetic Marks

According to a study in Development and Psychopathology, the amount of comforting and close contact between human caretakers and their babies can influence the amount of DNA methylation, an epigenetic mechanism connected to turning genes “off.” This adjustment to the children’s DNA may even persist several years later.

Methylation describes the addition of a methyl group, consisting of hydrogen and carbon atoms, to a specific area of DNA. These small molecules act to suppress gene expression, thus affecting how cells function.

(...)

However, when the team expanded their view and looked across the entire genome, they found significant differences in methylation levels in other areas. They pinpointed consistent differences in methylation between children who received a lot of contact versus those who received little contact to five specific DNA sites. Of these five sites, two of them were located within genes related to the immune system and metabolism. Still, the downstream influence of these epigenetic differences on child development and health later in life remain unknown.

Can We Reverse Marks on DNA?

Although it may sound like someone could be “epigenetically doomed” to bad health if their parents didn’t cuddle them enough, it’s interesting to consider other studies which suggest that epigenetic marks might be reversible. In a mouse study, for example, male mice were separated from their mothers repeatedly and, as a result, experienced early-life trauma which left distinct epigenetic marks behind on their DNA.

They even passed down these marks and the negative behavioral consequences that accompanied them. But, what’s more intriguing is that the mice’s behavior returned to normal when they lived in pleasant environmental conditions as they grew, and their offspring developed normally. The results demonstrate that negative effects of trauma might be corrected by an enriched environment with low stress in adult life.

If this is the case, it may be possible that children who are not shown enough affection as infants may be able to overcome any shortcomings if they’re given the proper care or exposed to a positive environment later on. As more research is carried out, we can begin to understand the far-reaching implications early life experiences have on our epigenome, our behavior, and our health.

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mirage29
Knowflake

Posts: 13373
From: us
Registered: May 2012

posted June 15, 2020 11:45 AM     Click Here to See the Profile for mirage29     Edit/Delete Message   Reply w/Quote
Food, AND lots of Hugs!!! … are Medicinals.
Important shares...
thank you

I was brought up in a very cold detached home atmosphere. Lots of 'neglect' as a "person" growing up.

It did make an impact on my life,
and my ability to 'receive'.

________________________
Oh no! What happened to the post after Phoenix.

It went MISSING,,,,, .
We've had a Glitch here?

*twilight zone*
___________________________

Oooookayyyy. It's BACK.
We've got Gremlins!!! haha

Thanks for your add, Ilunatique.
Yours was the post that went missing for a moment, and was replaced by another persons post.

All POOFED BACK to 'as it should be'.
whoooooahhh.

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Randall
Webmaster

Posts: 128914
From: From a galaxy, far, far away...
Registered: Apr 2009

posted July 12, 2020 05:50 PM     Click Here to See the Profile for Randall     Edit/Delete Message   Reply w/Quote
Bump!

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