Bob H -It's may be helpful to say what sign they are in too. I have a link to more on the 12th House, which also talks about if Pluto is there, http://meinah.tripod.com/AI/12thhouse.html
and below something about Jupter in the 12th I had.
The 12th is commonly known as the "House of Undoing". The 12th's natural ruler is the planet Neptune, and Neptune is about the "hidden side". It can indicate where you can become your own worst enemy, hence, the potential "undoing"...
"Jupiter:
Depending upon the level of dignity here it can either mean a guardian angel that one is not aware of, or a lack of awareness of proportion leading to excesses and errors of judgement. Valens suggests that the benefics have a hard time delivering their beneficial effects here. [75]
Because Jupiter is also related to legal issues and religious matters, it can indicate that monks, clergy, lawyers may tend to dislike the native. According to Paulus: "...it will make rebellions of enemies, litigations with those of least account, and diminution of one's patrimony, except that in the determination concerning slaves and quadrupeds, it is good and helpful". [76]
This would be the case because the native is in aversion to these types of individuals and lack of familiarity breeds contempt. The solution to this type of problem is identification, learning tolerance and empathy. Because Jupiter represents opportunity in can mean an aversion to this or a lack of awareness of its existence reflecting a lack of broadness or perspective.
I believe the opposite is the case if Jupiter is in dignity, or is received and in sect, and some believe it to be an idicator of good deeds in the past life that rewards protection in this one."
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it's better to light a candle than curse the darkness...