trine is nice and smooth, but not really all that eventful usually (grand trines might be a different matter). my pSun is trine my natal DESC 0°35 s
also is applying to trine my natal Pluto in about 1-2 years.
Nothing ever get neutralized, but of course if multiple aspects are simultaneously happening, this will modify the results or how you experience it.
Tr Saturn square natal ASC is a biggie though, I can`t imagine it to not be felt in some way (does not need to be all that bad, could make you more serious about commitments for example, or alternatively feel like a drag. It probably depends how well you deal with Saturn in general)