OMG thank you so much for starting this. I LOVE nodal astrology, I feel it's by far the most helpful aspect of astrology.My SN is in Cancer in the 12th house. I believe my past lives involved being a monk and/or being imprisoned somehow, especially in a mental asylum. I suspect this because the latter particularly elicit my compassion to the point of pain, and I suspect a monastic life because of the things I seem to know subconsciously, things that seem obvious to me when they are not to others. However, I believe that because of the 12th house SN, my past lives have been sealed to me. I have been told that my soul goes way back and that I was an actor in Ancient Greece!
I have always been called "motherly" even though I don't feel that way. (My ASC is in Cancer too though.) I appear very sensitive to people even though I don't like to think I am that way. I have tended towards romanticism and over-sentimentality. I prefer being at home. At 25 I still live at home, although that's also pretty normal nowadays. I have a lot of trouble with mother figures in my life: I was adopted, then my adoptive mother and I stopped speaking and became estranged, and I have another mother figure who recently I realized doesn't really like me. So there is a lot of pain surrounding the maternal theme, and I don't plan on having kids.
I feel the 12th house SN even more. I prefer to be isolated and to deal with philosophy and spirituality rather than to go out in the world and interact with people. (Although I have a lot of personal planets in the 10th and 11th houses so that makes it much easier. But it's in an impersonal way. I like to relate to individuals on a broad, philosophical basis rather than on a super personal, intimate level.) I have never struggled with addiction though, and I've actually always been averse to drugs and alcohol. However, my mother was an alcoholic.
I have never felt very connected to my body. I have not paid attention to its needs. Personal hygiene, a good diet, and exercise (6th house stuff) are all very difficult for me. I am a big picture person, not a details person. I will walk out of the house and forget my shoes. That kind of thing.
The most helpful description of the 6/12 axis I've found is "the existence axis." On the 12th house end, you have the big, philosophical questions about life. That's what I'm good at and what I'm drawn towards. On the 6th house side, it's the daily routine, details, and taking care of the body. That's the stuff I'm bad at. I have a lot of strongly Virgo-influenced people close to me and I think they're here to help me with that (and I'm here to help them chill the f--- out!). However, they are also my most challenging relationships sometimes. But I would not have survived this far without them.
With my SN in double water (Cancer and 12th house) the emotional, intuitive world is where I'm most comfortable. It's going out into the world and building something that's hard.
On an even more personal note, I believe my soul purpose is to bring the wisdom of of 12th house and compassion/sensitivity of Cancer to the world through my work (Capricorn), which I must accomplish through disciplined daily routines (6th house) and their details. I am a writer and illustrator, so everything I do is about bringing wisdom and sensitivity into some kind of physical (earth) form. My work deals with the "big questions", bringing awareness to the "transcendental ground" as it's described in the perennial philosophy, environmentalism, etc.
Shakespeare also had his SN in the 12th (in Gemini) and you can see how his work really manifests the "existence" idea. What is more existence axis than "To be or not to be?" Virginia Woolf, John Lennon, Paul McCartney, Jim Morrison, and Sigmund Freud are some others. It's really interesting to consider how this manifests in one's life and work.
I may add some more responses later based on my friends' nodes. I study them all the time.
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Sun - Taurus // Moon - Aries // ASC - Cancer // Mercury - Aries // Venus - Taurus // Mars - Pisces