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Randall
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From: Saturn next to Charmaine
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posted April 16, 2015 07:03 PM     Click Here to See the Profile for Randall     Edit/Delete Message   Reply w/Quote
According to a group of researchers from around the world (including those from London and various regions in Spain), people who have suffered from abuse during their childhood are more likely to be diagnosed with clinical depression — and even more so if they are genetically predisposed to the condition.

Over a three-year period, scientists analyzed patients from 41 different health clinics in seven Spanish provinces who ranged in age from 18 to 75. And here’s what they discovered through genetic testing: The participants who were shown to have limited gene function implied in both BDNF (brain-derived neurotrophic factor, a protein-coding gene) and serotonin transmission were extra-sensitive to the damaging effects of child abuse — whether the abuse was psychological, physical or sexual. In other words, this particular lack of gene activity mixed with an abusive history can result in an increased risk for suffering from depression.

Blanca Gutiérrez, a professor in the psychiatry department at the University of Granada and the lead coordinator of this study, says that these findings — which were recently published in the Journal of Psychiatry and Neuroscience — are significant in terms of treatment.

“It is an important result, which proves a triple genetic-environmental sort of interaction whose relevance is even more important if we take into consideration that the response to antidepressants appears to be fundamentally mediated through proteins codified by the two genes we have studied,” she states in a press release.

“Our results present a fundamental genetic-environmental model to explain this sort of therapeutic response.”
http://www.yahoo.com/health/the-number-one-cause-of-depression-everywhere-116497956847.html

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Peluches
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posted April 16, 2015 08:31 PM     Click Here to See the Profile for Peluches     Edit/Delete Message   Reply w/Quote
Oh God, it's true. I'd have never thought they would be that linked.

Thank you, Randall.

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Catalina
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posted April 17, 2015 01:18 PM     Click Here to See the Profile for Catalina     Edit/Delete Message   Reply w/Quote
It can be argyed that we are all abused...in a society that requires us to deny our reality in order to "fit in"..does anyone know anyone whose depression was really cured in the long term by SSRIs? Everyone I know who has tried them has been very disappointed if not damaged...and look at all the medicated mass shooters...?

I agree theres a predisposition and early environment can add or subtract from the tendency...but not always from abusive family or even bullies in the environment...the most well-meaning caretakers can reinforce it unintentionally...

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Ami Anne
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From: Pluto/house next to NickiG
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posted April 17, 2015 01:28 PM     Click Here to See the Profile for Ami Anne     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Peluches:
Oh God, it's true. I'd have never thought they would be that linked.

Thank you, Randall.


Yes, I felt this way on my own, with no study lol

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DeepFreeze
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posted April 17, 2015 02:49 PM           Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Catalina:
It can be argyed that we are all abused...in a society that requires us to deny our reality in order to "fit in"..does anyone know anyone whose depression was really cured in the long term by SSRIs? Everyone I know who has tried them has been very disappointed if not damaged...and look at all the medicated mass shooters...?

I agree theres a predisposition and early environment can add or subtract from the tendency...but not always from abusive family or even bullies in the environment...the most well-meaning caretakers can reinforce it unintentionally...


I'll have more on this later. Strictly my opinion.

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DeepFreeze
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posted April 17, 2015 05:15 PM           Edit/Delete Message   Reply w/Quote
This is a lot, just my opinion. Keep that in mind.

First, let's look at SSRI's, which are very widely used. Other types are used as well that work in similar ways such as with Dopamine, which is somewhat related to cocaine. Anyway, SSRI (Selective Serotonin Re-uptake Inhibitors) work by slowing down how quickly the body reabsorbs Serotonin. Serotonin is a chemical produced by us when we have happy/pleasurable moments. After the moment has passed then the Serotonin is reabsorbed. Blocking/slowing this re-uptake fools the brain into feeling happy as the chemical is flooding the brain.

Problems such as depression are growing, along with bullying, speed of information, stress, more focus on body image, etc etc. To me, it seems like there are less frequent "moments" that create conditions which cause us to produce Serotonin. Therefore, medication is becoming widely used. I personally don't mind it as a temporary fix, but the root is not being properly addressed. Plus, let's say someone at school is being bullied. Socializing with their friends may have a much less powerful effect as they may constantly be on watch for the bullies next move and stress lingering on from the last one.
Myself as an example, I need more moments where I express my creativity through arts and crafts. I need to escape into the woods, sit in the grass and just chill in the sun, be silly in some ways like I was when I was a kid.
I think some of these people need more of whatever makes them feel free and happy. Perhaps for some it's hanging out with friends, etc. By doing this, it's like exercising. It's better when it's constant, not just one day a week. We could keep our brains with a steady flow of serotonin. Thus eliminating the need for medication is many, many cases.

I mean, sure there are many causes, types, etc etc.
Again, it's just my opinion. I think it'd really help. People are spending too much time chasing money, or an image, etc, etc.

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Catalina
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posted April 17, 2015 06:44 PM     Click Here to See the Profile for Catalina     Edit/Delete Message   Reply w/Quote
I have seen too many people take SSRIs and receive temporary relief from depression only to start experiencing chronic physical pain, which is one of the most depressing conditions to live with..and then return to feeling suicidal due to the abject failure of the meds to alleviate their depression and paiin. Thar one of the primary side effects in the printout for, say, Prozac, is suicidal feelings makes it clear I am not alone in this observation.

DNA has been pretty well proven to be malleable through nurture so I think telling people they are genetically depressed is counterproductive..

I have similar therapies, DF, along with massage and exercise which have helped me get through many decades now with little depression though when younger I had bouts with it.

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DeepFreeze
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posted April 17, 2015 08:33 PM           Edit/Delete Message   Reply w/Quote
Yep. They use those kinds of therapies when people are committed to mental health hospitals. (Arts and crafts)

I know that I've found myself spending too much time stimulating my mind (Virgo mercury / Gemini moon love it) but I burn myself out.

I didn't read the article but yeah, one of my sisters has a tendency to dwell on the past and has had issues with depression. I have also but it hasn't ever been related to the past. More just, life and the world we live in.

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DeepFreeze
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posted April 18, 2015 12:53 PM           Edit/Delete Message   Reply w/Quote
I love this!!!
I had to share it!
The struggle that I have...

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Ami Anne
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From: Pluto/house next to NickiG
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posted April 20, 2015 03:35 PM     Click Here to See the Profile for Ami Anne     Edit/Delete Message   Reply w/Quote
I think the Psych drugs do a great deal of harm. It is very sad that drugs are thrown at people when the problem is a soul sickness, spiritual sickness and/or a societal sickness. This is one of the sadder things of our age, although there are many others

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Swanlake
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posted May 29, 2015 03:00 AM     Click Here to See the Profile for Swanlake     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Ami Anne:
I think the Psych drugs do a great deal of harm. It is very sad that drugs are thrown at people when the problem is a soul sickness, spiritual sickness and/or a societal sickness. This is one of the sadder things of our age, although there are many others


I agree 100%. I also find it absurd how the science establishment attempts find answers by clinically micro dissecting everything and totally missing the big picture.

Really life today, the way people are forced to live is INSANE.

I LOVE this quote by Krishnamurti -
"It is no measure of health to be well adjusted to a profoundly sick society"

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Ami Anne
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From: Pluto/house next to NickiG
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posted May 29, 2015 08:24 AM     Click Here to See the Profile for Ami Anne     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Swanlake:
I agree 100%. I also find it absurd how the science establishment attempts find answers by clinically micro dissecting everything and totally missing the big picture.

Really life today, the way people are forced to live is INSANE.

I LOVE this quote by Krishnamurti -
"It is no measure of health to be well adjusted to a profoundly sick society"



Yep, you said it all, S!

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