posted May 24, 2009 11:03 PM
kat ~Here's an article from Dr Russell Blaylock. Dosage Answer: take about 2,000iu per day. I have a D-3 supplement that is exactly that dosage. As I have psoriasis (an inflammatory, auto-immune malfunction) I'm going to try the 4,000iu level. I give a tab daily to my 13yo too.....
Vitamin D’s Hidden Role in Your Health
You probably already know that vitamin D builds strong,
healthy bones. But that’s only part of the story — and a small part
at that. In fact, vitamin D is essential for all-around good health.
Without it, cells could not perform their functions and the brain
would not fully develop.
Despite its many benefits, vitamin D has had a hard time making
its way into our bodies in the past.
In the 1970s and ’80s, the medical establishment, led by
dermatologists, sounded an alarm over the rising number of
malignant melanomas in the United States.
Malignant melanoma is one of the few skin tumors that can
actually kill. Since doctors believed that most skin cancers were
the result of too much exposure to UVB rays from the sun, they
launched a campaign to convince people to protect their skin from
the sun’s rays. This included the use of broad-brimmed hats, long
sleeves, and the liberal use of sun blockers. Unfortunately, instead
of correcting the problem, they only made it worse.
Cases of melanoma actually rose in significant numbers. Medical
experts blamed the increase on the fact that people were spending
more time in the sun because they felt protected by sun-blocking
creams.
Only later did new research reveal that the sun’s UVA rays,
which were not blocked by most sun blocks, were just as
carcinogenic as UVB rays.
Sun Exposure and Vitamin D
While this is important, they may still be missing the boat. When
sun strikes our skin, the penetrating UVB rays trigger biochemical
reactions in the deeper cells that generate huge amounts of
vitamin D.
As little as 30 minutes in the sun can generate up to 50,000
international units (IU) of vitamin D. We now know that vitamin
D is a powerful inhibitor of cancer development and growth.
So by making people vitamin D deficient with their medical
wisdom to avoid sun exposure, they inadvertently increased
people’s risk of developing all forms of skin cancer, including the
deadly malignant melanoma.
Vitamin D plays a role in reducing major
medical problems including heart disease, cancer,
and osteoporosis.
Medical experts have long known that vitamin
D is essential for promoting calcium absorption in
the intestinal tract and helping the body build and
protect bones.
Vitamin D is a fat-soluble vitamin that is found
naturally in large quantities in few foods, other
than fish.
Nicknamed “the sunshine vitamin,” the major
source is rays from the sun, which the body uses
to make vitamin D. But getting enough sunshine
to produce our own vitamin D has been strongly
discouraged, and, as a result, the average person’s
level of vitamin D has plummeted.
There are a number of safe ways to use the sun
to make vitamin D, without increasing your risk
of skin cancer and skin aging, which I will outline.
But first, I will share with you some of the new
things we have learned about vitamin D — some
that will surprise you.
What Is Vitamin D?
Vitamin D is a very complex substance. For
over half a century vitamin D was thought only to
mineralize bones. But studies indicate that it does
much more:
• Regulates calcium in all cells (especially brain
cells)
• Protects the immune system
• Regulates cell growth and cell death
• Provides antioxidant and antiviral benefits
Since foods contain very little vitamin D, the
body’s major source is from that manufactured in
the deeper layers of the skin. The UVB wavelength
from sunlight activates 7-dehydrocholesterol (7-
DHC), transforming it into a precursor form of
vitamin D-3.
It then changes to active vitamin D-3 and enters
the blood stream where it is distributed all over
the body.
Vitamin D from foods is metabolized in the liver
and the kidneys to form the active vitamin D-3.
Many forms of commercial vitamin D
supplements are not the active form. So, when
you buy vitamin D supplements make sure it is
vitamin D-3.
Vitamin D-3’s Impact on the Brain
One of the most exciting findings is that
vitamin D-3 is a neurohormone, and like other
neurohormones in the brain, it plays a number of
roles in brain function.
Recent research has shown that all cells in the
brain have receptors for vitamin D-3, both in the
nucleus and on their membranes.
A number of recent studies have found that
these vitamin D-3 receptors play a major role in
brain development, both while the baby is in the
uterus and after it is born.
Low vitamin D intake or low exposure to
the sun by moms-to-be can result in behavioral
problems when the child is older. With acute
vitamin D-3 deficiencies, the brain’s growth can
suffer severe abnormal development, because this
critical vitamin controls how the brain develops.
Food, even fortified milk, is a poor source
of vitamin D-3. This leaves sun exposure and
vitamin D-3 supplements as the two most
important sources.
In the past, mothers made their children
take cod liver oil, a concoction that contained
substantial amounts of vitamin D.
As medical practice became oriented more
towards pharmaceuticals, this ritual seemed
archaic.
Modern medicine has a bad habit of promoting
the abandonment of healthful folk treatments —
such as B-12 shots for the elderly and cod liver oil.
Vitamin D-3 plays a major role in a number
of mechanisms that protect the brain, such as
increasing neuron glutathione level. It is also a
powerful antioxidant.
In addition, it also reduces harmful levels of
nitric oxide, which can form a brain-destroying
free radical called peroxynitrite.
This radical is found in high concentrations
in the brains of people with Alzheimer’s disease
as well as a number of other neurodegenerative
diseases of aging.
Vitamin D-3 and Autism
Vitamin D-3’s role in the development of the
brain begins when the human brain undergoes its
most rapid and complex formation between the
last trimester of pregnancy and the first two years
of life. In studies of the development of rat brains,
which are very similar to humans in terms of
vitamin D-3, vitamin D-3 deficiencies have their
most devastating effects during the last trimester
of pregnancy.
Studies on rats showed that feeding pregnant
rats a diet deficient
in vitamin D-3 led to
behavioral problems when
the offspring grew up. This
was mainly manifested as
high excitability, something
we see in ADHD and
autism. Vitamin D-3
deficiency in pregnant
animals has also been
shown to negatively impact
the brain in the offspring:
• Shrinking of the brain
was observed
• Abnormal levels of
brain growth factors
occurred
• Formation of abnormal
neurons occurred
One effect of vitamin D-3 deficiency during
pregnancy is the appearance of an excess number
of brain cells, which is characteristic of autistic
brains.
Further connections to autism include a state of
hypersensitivity that causes the brains of babies
whose mothers are deficient in vitamin D-3 to be
oversensitive to the harmful effects of multiple
vaccinations and infections.
According to today’s vaccine recommendations,
children receive some 36 vaccines by the age of
2, a period when the brain is most sensitive to
such injury. A vitamin D-3 deficiency makes their
brains even more susceptible to damage.
The brain’s immune cell is called the microglia
and it contains a number of vitamin D-3
receptors. Newer studies indicate that these
receptors play an important role in reducing the
damaging reactions triggered by vaccines as well
as other toxins such as mercury.
Vitamin D-3 has been shown to significantly
soothe activated, angry microglial cells, thus
calming the brain’s hypersensitivity.
Recent studies have found widespread,
prolonged microglial activation in the brains of
autistic individuals lasting from age 3 to 45 years.
This means that their brains are inflamed for very
long periods, even decades. Vaccines can produce
this reaction, especially in the face of vitamin D-3
deficiency.
It would be interesting
to know the incidence of
vitamin D-3 deficiencies
during pregnancy in mothers
of autistic children.
One study found that
vaccination impaired the
functioning of vitamin D-3.
Interestingly, autism is
more common in blacks
than whites.
Dark-skinned people are
especially prone to vitamin
D-3 deficiency because they
cannot absorb as much
sunlight.
In essence, it may be
that a maternal vitamin
D-3 deficiency sets the stage for autism. When
combined with the right genetic propensity (which
is linked to a high risk of autoimmune disorders),
activating an immune reaction in the brain may
trigger the effects on brain development associated
with autism.
A number of factors can trigger
immunoexcitotoxicity in the brain:
• Ethylmercury (in vaccines as thimerosal)
• Aluminum, repeated vaccinations (especially
closely spaced)
• Recurrent infections
All have been associated with autism.
Protecting the Aging Brain
As we age, our brains become more inflamed.
With neurodegenerative diseases, such as
Alzheimer’s disease and Parkinson’s disease, we
see much higher levels of brain inflammation.
This reaction in the aging brain can lead to
a loss of vital brain cells in the memory and
cognitive parts of the brain (hippocampus and
prefrontal lobes).
It has been shown that vitamin D-3 deficiency
is very common in the elderly. This makes sense
because so many are house-bound and avoid sun
exposure.
Many also have GI problems that interfere with
vitamin D absorption. While the average diet is a
poor source of vitamin D, the diets of many senior
citizens are even worse.
Studies have shown that vitamin D-3 can
protect the normal aging brain from neuron loss,
especially in the memory areas of the brain, the
hippocampus. This means that a higher intake of vitamin D-3
can protect your memory.
Vitamin D-3 and Alzheimer’s Disease
A compelling number of studies have shown
that Alzheimer’s disease is another brain
inflammatory disorder, characterized by the
following:
• Intense inflammation,
• Microglial activation
• Free-radical generation
A number of conditions cause this inflammation,
many of which are present in all cases.
• Elevated brain mercury levels
• Elevated brain aluminum levels
• Chronic viral infections
• Head injury
• Repeated small strokes
• Exposure to certain pesticides and herbicides
All of these things trigger immunoexcitotoxicity,
which is made much worse if a person is deficient
in vitamin D-3. This may be another reason why Alzheimer’s
dementia increases the older we get, from 3
percent to 5 percent at age 70, to 43 percent over
age 80.
Vitamin D-3 and Parkinson’s Disease
Parkinson’s disease is another neurodegenerative
disease of aging that is strongly related to chronic
brain inflammation, but different parts of the
brain are involved than in Alzheimer’s disease.
The primary sites of the inflammatory damage
are the substantia nigra, a part of the brain
perched high on the brain stem, and the locus
coeruleus, a brain nucleus located lower on the
brain stem.
Page 4 The Blaylock Wellness Report September 2008
In previous newsletters I pointed out the strong
connection between Parkinson’s and exposure to
commonly used pesticides and herbicides.
I also noted that vaccinations can dramatically
increase one’s sensitivity to these brain poisons,
making even very small exposures very toxic.
Remember this when your doctor pressures you
to get a flu shot!
New studies have also shown that deficiencies in
vitamin D-3 can cause poisons, such as pesticides
and herbicides, to have the same sensitizing effect.
In one study, scientists found that dogs exposed
to a drug that damages certain sensitive brain cells
developed symptoms of Parkinson’s disease. But
when they were given high doses of vitamin D-3
for eight days, their symptoms improved.
A Japanese study found that giving vitamin D-3
before exposure to toxins protected the neurons
from damage.
This means that your best protection against
developing neurodegenerative diseases is to
take vitamin D-3 in higher doses than the
recommended daily allowance (RDA) every day to
attain maximum protection. Don’t forget vitamin
D-3’s many benefits:
• Cools down the activation of microglia
• Blocks excitotoxicity
• Reduces brain immune reactions
(immunoexcitotoxicity)
Vitamin D-3 and Depression
People’s moods change with seasons. They are
more often depressed and anxious during the
winter months and less so during the summer.
Extreme degrees of this are called seasonal
affective disorder (SAD). SAD is associated with
the following conditions:
• Carbohydrate cravings
• Daytime sleepiness
• Lack of energy
• Severe depression
Researchers have linked the variations in mood
to seasonal exposure to sunlight, which links a
lack of vitamin D-3, to this disorder.
Newer research has disclosed several possible
explanations for this association. We know
that high stress levels can cause blood levels of
corticosteroid, the stress hormone, to increase.
Over time, corticosteroid can damage brain cells
in the limbic system associated with memory and
mood.
Corticosteroids increase excitotoxic damage to
these neurons, but one study found that vitamin
D-3 can reduce the damage, especially in the
hippocampus.
The limbic system, which regulates mood as
well as memory, also contains a high density of
vitamin D-3 receptors, which are especially dense
in the hippocampus.
Another nuclei within this limbic system called
the amygdala, also contains a dense concentration
of vitamin D-3 receptors.
As I pointed out in the newsletter on depression
and anxiety, “Overcome Depression and Its
Deadly Effects” (March 2008), the new theory
of these mood disorders is based on the idea that
the brain accumulates too much limbic glutamate,
and glutamate, in combination with immune
overactivity (immunoexcitotoxicity), triggers
depression and anxiety.
Vitamin D-3 and Cancer Risk
As a powerful regulator of cell reproduction,
vitamin D-3 plays a major role in preventing
cancers and controlling the growth and spread of
existing cancers.
I mentioned the malignant melanoma and its
relation to sunlight exposure.
Higher doses of vitamin D-3 have been shown
to slow cancer growth by inhibiting cancer
cell reproduction. It also makes the immature
(undifferentiated) cells become more mature
(differentiated), which has always been the dream
treatment of cancer specialists.
It does this by regulating a number of complex
cell signaling processes.
Studies have shown that vitamin D-3 can make
melanoma cells more like normal cells and reduce
their growth. Likewise, studies in patients with
melanomas have shown that high doses of vitamin
D-3 strongly inhibit the spread of the melanoma,
which is what kills.
People inheriting deficiencies in vitamin D-3
receptors (which makes vitamin D-3 work in the
body) have a much higher incidence of malignant
melanomas upon exposure to sunlight.
Vitamin D-3 is also known to inhibit the
development of some of the worst cancers:
• Breast
• Colon
• Prostate
Yet, the most dramatic effect on cancers is with
the deadly glioblastoma multiforma, the most
common primary brain tumor and the form that
has stricken Ted Kennedy.
The mortality is around 90 percent and most
die within one to two years of diagnosis despite
aggressive conventional treatment.
Studies of animals with glioma-type tumors
(similar to the glioblastoma) have shown that high
doses of vitamin D-3 cause the cancerous glioma
cells to commit suicide (called apoptosis). One of
the most encouraging studies used actual patients
with glioblastoma multiforme brain cancer.
In a Phase II trial, researchers found that high
dose vitamin D-3 produced a dramatic regression
of the tumor and complete clinical remission in
27 percent of cases that lasted as long as four to
seven years, far beyond the expected survival with
conventional aggressive treatments.
One of the key triggers for cancers is the
generation of free radicals. This trigger is
secondary to chronic inflammation. Iron
accumulation plays a major role in cancer
development and its growth and spread. Vitamin
D-3 has been shown to be a powerful antioxidant
and to dramatically reduce iron-induced free radical
generation.
Another way vitamin D-3 fights cancer is by
inhibiting immunoexcitotoxicity.
We know that activation of glutamate receptors
on cancer cells causes the cancer to grow faster
and spread more rapidly. Glioblastomas that
secrete glutamate grow 15 times faster than those
that don’t. (As a side note, most processed foods
contain high levels of glutamate additives.)
Vitamin D-3 and Autoimmune Diseases
There are over 80 known autoimmune diseases
that affect people, mostly women. There is
growing evidence that the incidence of these
disorders has increased dramatically over the past
30 years, most likely because of the great number
of vaccines being given. The tetanus, HepB, MMR
and DPT vaccine have been the worst offenders,
but newer vaccines may be worse. Over 150
vaccines are now being proposed for people
during their lifetime!
I will consider a select few of the autoimmune
diseases to discuss, including multiple sclerosis
(MS), irritable bowel disease (IBD), rheumatoid
arthritis and insulin dependent diabetes (IDDM),
but the information is pertinent to a great number
of additional autoimmune disorders.
A link to low vitamin D-3 levels has been found
in all four of these diseases.
One of the clues was that all of these disorders
are more common in the higher latitudes, which
include Canada, northern United States, and
northern Europe, and they get worse during
winter and spring. Why spring?
Because there is a two-month lag before the
effect of rising vitamin D-3 levels takes hold.
It is also known that people who inherit a
deficiency in the vitamin D-3 receptors on their
cells have a higher incidence of autoimmune
diseases of all types.
Recently, researchers found that a definite
correlation exists between sunlight exposure and
the worsening of MS symptoms: Symptoms were
worse during the winter and spring.
Further research found that the incidence of
MS itself was much lower with greater overall
exposure to sunlight.
In one of the largest studies of its kind involving
187,000 people who were followed from 10 to 20
years, researchers found a 40 percent reduction
in MS in those with the highest blood levels of
vitamin D-3.
Most of the vitamin D-3 came from vitamin D
supplements. Another study of 29,000 women
found a strong correlation between vitamin
D-3 blood levels and a reduced incidence of
rheumatoid arthritis. We also know that vitamin
D-3 deficiency is common in Crohn’s disease and
insulin-dependent diabetes.
Daily doses of cod liver oil containing 5,000 IU
of vitamin D were shown to reduce MS symptoms
by an incredible 2.4 to 2.7-fold. Not surprisingly,
MS is another neurological disorder triggered by
immunoexcitotoxicity.
Experimental studies using mice with these same
human diseases as models also show a dramatic
improvement when treated with vitamin D.
For example, in the mouse model of MS,
vitamin D-3 will prevent the disorder if given
before the disease develops and will halt the
disease in its tracks if it has already started.
Making the animals deficient in vitamin D-3 will
dramatically increase the incidence and severity of
autoimmune diseases.
One of the interesting effects of vitamin D-3
is that it switches the immune system from an
inflammatory state that’s associated with most
autoimmune diseases, to a condition that inhibits
inflammation.
Vitamin D-3 and the Flu
A friend sent me a paper that discusses the
work of Dr. R. Edgar Hope-Simpson, the self-educated
epidemiologist who discovered the cause
of shingles. He turned his incredible skills to
observations concerning sunlight exposure and flu
epidemics. What he discovered was that latitudes
determine the flu epidemics, just as we saw with
multiple sclerosis.
The elderly are more severely affected by the flu
because they have lower vitamin D-3 levels and
cannot make as much vitamin D-3 in their skin as
younger people.
He also observed that the Norwegians have less
sun exposure than any other Europeans, yet they
have fewer flu epidemics and a lower mortality as
well.
The reason is that they eat a lot of fish oil,
which is high in vitamin D-3.
The vitamin D-3 link also explains why
black children get pneumonia twice as often as
Caucasian children and why blacks are more
likely to die of respiratory infections and flu
complications.
Blacks make less vitamin D-3 with sun exposure
than Caucasians. In fact, their skin must be
exposed to 10 times the sunlight to make the
same amount of vitamin D-3 as a person with
white skin.
Rather than spending vast amounts of taxpayer
money promoting ineffective and dangerous flu
vaccines, maybe health officials should be handing
out vitamin D-3 supplements, especially to babies,
small children, and the elderly.
What Are Recommended Doses?
Recent reviews by health “experts” have revised
the recommended doses for vitamin D from 400
IU to 2,000 IU a day, a dramatic five-fold increase.
This means that the “experts” have been keeping
people in danger of contracting a number of
serious diseases, many deadly, for over a century
— more bad advice from a government that is
quickly moving to control all of your health
decisions (universal healthcare).
A recent paper by Dr. Cantorna of the
Department of Nutritional Sciences at
Pennsylvania State University and a recognized
authority on vitamin D, recommended that people
of all ages should take 2,000 IU of vitamin D-3 a
day. This dose was given to 10,366 children in a
study and found to be perfectly safe.
The optimal blood levels to prevent bone
fractures is 50 nM (20ng/ml), which can be
attained by taking 1,000 to 2,000 IU of vitamin
D-3 a day.
Lifeguards and people who work outdoors have
blood levels of 100 nM (40 ng/ml). There is no
known vitamin D-3 toxicity with any level of sun
exposure.
A dose of 800 IU a day (twice RDA levels) has
no effect on bone fracture reduction, but 2,000 IU
a day produces a profound reduction. At 4,000
IU a day there is no reported hypercalciuria (a
condition that causes kidney stones), a previous
fear of the “experts.”
Daily doses of 10,000 IU or less have been
shown to produce no complications.
For daily maintenance in otherwise healthy
people, 2,000 IU a day appears to be adequate.
For those with autoimmune diseases, cancer or
viral illnesses, higher doses may be needed —
doses as high as 5,000 IU a day.
So, what about those who want to use the sun?
The paradox is that sun exposure is associated
with aging of the skin and skin cancer, but it also
reduces the incidence of these same disorders. The
problem is that with extensive sun exposure the
skin’s antioxidants are rapidly depleted, leaving
the skin unprotected.
A number of studies have shown that a good
diet that replenishes lost antioxidants can protect
the skin against aging and cancer. The problem
is that most people eat diets that promote
skin aging and cancer, especially diets low in
fruits and vegetables, high in simple, processed
carbohydrates and high in pro-inflammatory
omega-6 oils.
Sun blockers still leave the skin unprotected,
because, at best, they block only 50 percent of the
UVA/UVB rays.
Vitamin D May Prevent
Multiple Sclerosis
Some studies indicate that a higher intake
of vitamin D may prevent MS, the crippler of
young adults. Modern science has concluded
that this terrible disease is the result of the
body’s immune system attacking its own
nervous system. Scientists have found that
people having the highest vitamin D levels had
the lowest incidence of MS.
It is known that vitamin D regulates the
immune system (called immunomodulation)
and tends to cool down the overactive immune
reactions seen in autoimmune diseases such
as multiple sclerosis.
Similar studies have shown low vitamin
D levels in people having other autoimmune
diseases such as immune thyroiditis,
rheumatoid arthritis, Sjogren’s syndrome,
lupus, and Crohn’s disease.
Epidemiologists have noted that diseases
such as MS are more common in northern
latitudes than southern and have hypothesized
a relation to sun exposure. Most of the vitamin
D we require is generated when our skin is
exposed to the sun. With the widespread use
of sunscreens and sun avoidance, vitamin D
deficiency has become more common.
Recommended levels of supplemental
vitamin D have recently been shown to be far
too low at 200 to 400 IU a day. The American
Journal of Clinical Nutrition found that safety
concerns with vitamin D toxicity are grossly
exaggerated and that the daily dose should be
2,000 IU a day.
Vitamin D-3’s Vital Role in
Controlling Seizures
A recent study of 285 people with epilepsy
found that almost half (44.5 percent) were
clinically deficient in vitamin D, especially the
men. Some anti-seizure medications lower
vitamin D-3 levels and several studies have
shown that supplementing with vitamin D-3 can
reduce the number of seizures and even increase
the effectiveness of anti-seizure medications.
One way vitamin D-3 prevents seizures is
by reducing excessive immune reactions in the
brain, a central cause in all seizures. Studies
of seizure patients have shown that most have
elevated levels of brain inflammatory cytokines.
Medications which are effective in reducing
seizures reduce inflammation and excitotoxicity.
Vitamin D-3 has also been shown to rid the
brain of free radicals, which are also associated
with seizures. This may explain why fish oil
supplements reduce seizures, since most contain
high levels of vitamin D, especially cod liver oil.
The DHA in the fish oil has other benefits as well:
• Reduces brain inflammation
• Reduces excitotoxicity (the process by which
nerve cells are killed by toxic substances)
• Helps repair injured brain cells
What Causes the Brain to Age
The secret of aging lies in commonly
occurring events in the body, something
shared by all cells. This common event is
the accumulated damage to vital cellular
components by free radicals.
Most of us have heard of antioxidants and
that they are good for you. Antioxidants are
substances that neutralize free radicals. So,
what is a free radical?
Basically, free radicals are highly reactive
submicroscopic particles that bounce around
inside a cell like red-hot BBs, burning
everything they touch.
Each cell is filled with delicate factories that
perform all sorts of vital functions:
• Generating energy
• Making enzymes and other proteins
• Storing information, as with DNA
Free radicals chip away at these cell
factories the way water dripping on a stone
wears the stone away. In the beginning, the
damage is so minute that little is harmed, but
over time the cell’s function becomes impaired.
The effects of this chipping away by free
radicals depends on the types of cells affected
and how severely they are damaged.
God also created a system to repair
much of this damage, but our poor diets and
constant exposure to environmental toxins
severely impair this repair system.
As a result, diseases are appearing earlier,
more often and to a much more severe
degree. This is true not only for diseases
affecting the brain but also for most other
diseases, including diabetes, autoimmune
disorders, many cancers, arthritis, heart
disease, and strokes.
All of these diseases share the same event:
massive production of free radicals over a long
period of time and a depletion of the body’s
antioxidant defenses.